Varanasi, India – Controlled release can be a powerful tool in drug delivery, enabling pharmaceuticals to be delivered slowly over time after a tablet or capsule is swallowed, or released at a specific point in the gastrointestinal tract. Polyurethane carriers can be used to achieve this, and scientists at the Indian Institute of Technology at Banaras Hindu University in Varanasi have been investigating the effects of different diisocyanates on release properties.

They looked at PU carrier systems based on TDI, MDI, HMDI and IPDI in the controlled release of the anticancer agent paclitaxel, which is hydrophobic. Studies were carried out in a phosphate buffer solution at pH 7.4.

Source: Utech-polyurethane